通过肠道微生物群介导的自愿运动的抗抑郁性质
Chihiro Watanabe1, Eri Oyanagi2, Takafumi Aoki3
1Graduate School of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Okayama, Japan.
Bioscience, biotechnology, and biochemistry
|September 5, 2023
概括
定期炼可以通过改变肠道细菌和减少有害化合物来预防抑郁症. 这项小鼠研究表明,运动会影响肠道微生物群,可能改善大脑健康和情绪.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 行为科学 行为科学
背景情况:
- 定期炼与预防抑郁症有关,但其对肠道微生物群及其潜在机制的影响尚不清楚.
- 肠道微生物群在运动中介抑郁症预防中的作用需要进一步研究.
研究的目的:
- 研究自愿运动对肠道微生物群组成和小鼠抑郁症类行为的影响.
- 探索运动,肠道微生物群变化和脑衍生神经营养因子 (Bdnf) 表达之间的关系.
主要方法:
- 小鼠接受了长达10周的静止控制或自愿轮子运行,随后是社会失败压力 (SDS).
- 评估了行为测试 (偏好糖),肠道微生物群分析 (便和便样本) 和大脑基因表达 (Bdnf,Zo-1,Claudin5).
主要成果:
- 运动减轻了SDS诱导的糖糖饮用量下降,表明抗抑郁作用.
- 运动改变了肠道微生物群,减少了特定的细菌 (Turicibacter,Allobaculum,Clostridium sensu stricto) 和酸.
- 运动增加了大脑Bdnf的表达,并减少了紧结蛋白 (Zo-1,Claudin5).
结论:
- 在小鼠中,自愿运动具有类似抗抑郁药的效果,部分是由肠道微生物群调节的介导.
- 肠道微生物群减少酸的产生可能会导致运动诱导的抗抑郁药物特性和改变血脑屏障的透性.
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