开发和验证动脉硬性的名图
Tingjun Wang1,2, Xiaoqi Cai3, Lingyu Zhang2
1Department of General Practice, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, PR China.
Journal of clinical hypertension (Greenwich, Conn.)
|September 5, 2023
概括
一个新的,低成本的诺米图模型有效地选了初级保健中的动脉硬性. 这种方便的工具有助于早期检测,克服了传统方法的局限性,例如动脉-大腿脉冲波速度 (cfPWV).
科学领域:
- 心血管健康 心血管健康
- 预防医学 预防医学
- 生物统计学 生物统计学
背景情况:
- 带 - 骨脉冲波速率 (cfPWV) 是测量动脉硬性的黄金标准,但由于时间和设备的限制,对于初级保健是不切实际的.
- 动脉硬是心血管风险的重要指标.
- 在初级卫生保健机构中,需要可访问和具有成本效益的查工具来检测动脉硬.
研究的目的:
- 开发一种方便且低成本的诺米图模型,用于查动脉硬.
- 评估开发的诺莫格拉姆模型的性能和临床实用性.
主要方法:
- 一项涉及2717名参与者的横截面研究进行,以构建名ogram.
- 最小绝对收缩和选择运算符 (LASSO) 和后勤回归被用于模型开发.
- 用ROC曲线,校准曲线,决策曲线分析和临床影响曲线评估模型性能,并进行内部和外部验证.
主要成果:
- 诺莫格拉姆模型包括年龄,性别,腰部和部的比例,静脉血压,糖尿病持续时间和心率.
- 该模型表现出良好的区分 (AUC = 0.820) 和准确性 (MAE = 0.005).
- 决策和临床影响分析表明了积极的净益处,验证结果令人满意.
结论:
- 开发了一种用户友好且低成本的名图,用于有效的动脉硬性查.
- 这种名ogram适合在初级医疗机构实施.
- 该模型为cfPWV提供了一个实用的替代方案,用于识别动脉硬的个体.
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