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Updated: Jul 17, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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用PROTACs针对可逆的翻译后修改:专注于修改蛋白质氨酸和氨酸残留物的酶

Marta Pichlak1, Tomasz Sobierajski2, Katarzyna M Błażewska2

  • 1Institute of Molecular and Industrial Biotechnology, Lodz University of Technology, Łódź, Poland.

Journal of enzyme inhibition and medicinal chemistry
|September 5, 2023
PubMed
概括

针对蛋白质溶解的仿真体 (PROTACs) 正在推动药物化学的发展. 本综述侧重于针对参与后翻译修饰的酶的PROTACs,为未来的药物开发提供结构性见解.

关键词:
E3 无处不在酸接酶这就是PROTAC.附带担保降低了退化情况.后翻译修改后的修改.蛋白质酶体降解的降解结构优化 结构优化

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