基于对比剂的 perfusion MRI 代码库和测试框架:ISMRM perfusion 成像开放科学倡议 (OSIPI)
Petra J van Houdt1, Sudarshan Ragunathan2, Michael Berks3
1Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
输液成像开放科学倡议 (OSIPI) 创建了一个共享代码库,以提高输液MRI的可复制性. 该计划成功地容纳了众多开源处理工具,并实施了定量 perfusion 成像测试框架.
科学领域:
- 医疗成像医学成像
- 软件工程 软件工程 软件工程
- 定量分析 定量分析
背景情况:
- 软件显著影响了定量 perfusion MRI 值.
- 缺乏标准化的代码共享和测试,阻碍了 perfusion MRI 研究和临床试验中的可重复性.
研究的目的:
- 建立一个社区驱动的,对基于对比度的输液成像开源代码的集中存储库.
- 整合一个开源测试框架,以确保代码质量和一致性.
主要方法:
- 在GitHub (OSIPI网站) 上创建了一个存储库.
- 选择Python作为编程语言.
- 开发了一个自动化单元测试框架来评估代码输出,包括视觉结果.
主要成果:
- 该存储库包含来自12个贡献者的86个 perfusion 处理实现,涵盖了 DCE 和 DSC-MRI.
- 在五个分析步骤中为52个实现开发了测试.
- 虽然T1映射和AIF函数显示一致的输出,但药理动力学模型在不同的实现中表现出参数变化.
结论:
- OSIPI 存储库提供了一个新的合作代码共享和测试在 perfusion 成像中的新模型.
- 这一举措加强了代码的重复使用和基准测试,最终促进了定量 perfusion MRI 的更高可重复性.
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