癌症中的蛋白质摄入量:它能改善营养状况和/或改变瘤对化疗的反应吗?
Martin Boutière1, Cécile Cottet-Rousselle1, Céline Coppard2
1Université Grenoble Alpes, Laboratory of Fundamental and Applied Bioenergetics (LBFA), Grenoble, France.
Journal of cachexia, sarcopenia and muscle
|September 5, 2023
概括
在接受化疗的癌症动物中,高蛋白摄入量没有影响瘤生长,但适度改善了营养状况和体重. 这项研究提供了有关癌症营养管理的见解.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 癌症研究 癌症研究
背景情况:
- 营养不良和缓解症是癌症护理中的重大挑战.
- 蛋白质摄入量在癌症中的作用是有争议的,对瘦体质的潜在益处与促进瘤生长的风险相比.
- 了解蛋白质的影响对于优化化疗中的癌症患者的营养至关重要.
研究的目的:
- 在动物癌症模型中,研究不同饮食蛋白质水平对缓冲症,瘤对化疗的反应和免疫反应的影响.
- 阐明癌症治疗期间蛋白质摄入量与身体组成,瘤进展和宿主免疫力之间的复杂关系.
主要方法:
- 一种患有结肠瘤的动物模型接受了化疗 (CPT-11和5-fluorouracil) 和含有8%至32%蛋白质的饮食.
- 测量包括每天的食物摄入量,体重,瘤大小,器官重量,身体组成和肌肉/瘤蛋白质合成 (SUnSET方法).
- 通过流式细胞计量来评估免疫功能.
主要成果:
- 癌症和化疗显著减少了脂肪质量和无脂肪质量.
- 饮食中的蛋白质水平没有影响身体组成,肌肉或瘤参数.
- 更高的累积蛋白质摄入量与更好的相对体重和无脂肪质量相关.
- 免疫系统受到癌症和化疗的影响,独立于蛋白质摄入水平.
结论:
- 在这种癌症模型中,饮食中的蛋白质摄入量没有调节瘤生长.
- 高累积蛋白质摄入量对接受化疗的动物的营养状况有中等的益处.
- 这些发现有助于了解癌症患者的营养管理策略,尽管临床伦理限制.
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