在接受关节置换术的老年患者中,用于手术内镇静的雷米马佐拉姆剂量与结合脊柱-外皮麻醉
1Department of Anesthesiology, Renhe Hospital Affiliated to Three Gorges University, Yichang City, Hubei Province, China. zxj19740974@163.com.
European review for medical and pharmacological sciences
|September 5, 2023
概括
该研究确定了在接受关节置换的老年患者手术内镇静时使用雷米马佐拉姆的有效剂量. 50%的有效剂量 (ED50) 是0.212 mg/kg/h,而95%的有效剂量 (ED95) 是0.288 mg/kg/h.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在外科手术过程中,内科镇静对于患者在手术过程中的舒适性至关重要.
- 由于生理变化,老年患者在镇静方面存在独特的挑战.
- 结合脊柱外皮麻醉 (CSEA) 经常用于关节置换手术.
研究的目的:
- 确定用于手术内镇静的雷米马佐拉姆的50%和95%有效剂量 (ED50和ED95).
- 评估Remimazolam在接受CSEA关节置换的老年患者的安全性和有效性.
主要方法:
- 对50名老年患者 (60-80岁) 的回顾性分析,他们接受了CSEA的关节置换.
- 修改的迪克森序列方法用于确定雷米马佐拉姆剂量.
- 使用双光谱指数 (BIS) 和修改观察者警觉/镇静评估 (MOAA/S) 评分来评估镇静.
主要成果:
- 雷米马佐拉姆的ED50为0.212毫克/千克/小时 (95% CI:0.121-0.231毫克/千克/小时).
- 雷米马佐拉姆的ED95为0.288毫克/千克/小时 (95% CI:0.254-0.884毫克/千克/小时).
- 不良事件包括过渡性胸,低氧,术后恶心和妄想;没有发生注射疼痛或低血压.
结论:
- 雷米马佐拉姆在接受用CSEA进行关节置换的老年患者手术内镇静时有效.
- 确定的ED50和ED95为临床实践提供了有价值的剂量信息.
- 雷米马佐拉姆在这个患者群体中显示出可接受的安全性.
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