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关于COVID-19患者早期死亡标志物的研究

B-Y Yuan¹, X-F Guo, X-W Gong

¹Department of Respiratory and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China. ydyuan1@hb2h.net.cn.

European review for medical and pharmacological sciences

|September 5, 2023

概括

严重的COVID-19患者的早期死亡指标包括心脏病,低淋巴细胞计数和高乳酸盐水平. MuLBSTA得分还预测了临界冠状病毒疾病2019病例的死亡风险.

科学领域:

关键护理医学关键护理医学
传染病传染病传染病
流行病学流行病学

背景情况:

2019年12月发现后,新冠肺炎疾病2019 (COVID-19) 在全球迅速蔓延.
识别早期死亡率指标对于管理严重和危急的COVID-19病例至关重要.

研究的目的:

调查严重和危急的COVID-19患者早期死亡指标.
确定与该患者群体死亡率相关的独立风险因素.

主要方法:

对162名严重和危急的COVID-19患者的回顾性队列研究,这些患者被送往武汉第七医院.
从电子病历中收集的临床数据.
用于确定死亡风险因素的单变量和多变量逻辑回归分析.

主要成果:

该队列的28天死亡率为31.5%.
没有生存的组显示白细胞数量显著增加,淋巴细胞数量减少,贫血和血栓细胞减少.
死亡的独立风险因素包括潜在的心脏病,低淋巴细胞计数 (<1.0×10^9/L),球过率受损 (<66),乳酸水平升高 (>2.2 mmol/L),SOFA得分更高,氧化指数更低和MuLBSTA得分更高.

结论:

潜在的心脏病,淋巴细胞计数,淋巴细胞过率,乳酸盐水平,氧化指数,SOFA得分和MuLBSTA得分与严重和危急的COVID-19患者的死亡风险有显著联系.
这些因素可以作为严重的COVID-19病例死亡率预测的重要早期指标.

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