随机临床试验:便微生物群移植治疗易怒肠综合征与腹
Yuk Kam Yau1,2,3, Qi Su1,2,3, Zhilu Xu1,2,3
1Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Alimentary pharmacology & therapeutics
|September 5, 2023
概括
便微生物种移植 (FMT) 并没有显著改善IBS严重性得分,但确实减少了患有刺激性肠综合征 (IBS) 的患者的胀气. FMT还改变了肠道细菌,减少了硫化的生产,没有严重的不良事件.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 临床试验 临床试验
背景情况:
- 刺激性肠综合征 (IBS) 影响了相当一部分人口.
- 便微生物群移植 (FMT) 正在作为治疗IBS症状的治疗选择进行探索.
- 以前的研究表明,FMT可能对一些IBS患者有好处.
研究的目的:
- 评估FMT在治疗腹占主导地位的IBS中的疗效.
- 评估FMT对IBS严重程度,胀气和肠道微生物群组成的影响.
- 为了确定FMT在IBS患者中的安全概况.
主要方法:
- 一项随机对照试验,涉及56名腹主导性IBS患者.
- 参与者在基线和第4周通过十二指管途径接受FMT或安慰剂.
- 主要结局:第12周IBS严重性评分系统 (IBS-SSS) 评分下降>50分.
主要成果:
- 在12周的FMT和安慰剂组之间,IBS-SSS得分减少没有显著差异 (57.1%对46.4%).
- 与安慰剂相比,FMT组的胀气明显改善 (72%对30%;p=0.005).
- FMT改变了肠道微生物群,减少了Ruminococcus gnavus和增加了Lawsonibacter,并减少了硫化生产途径.
结论:
- 每周两次的FMT并没有显著降低IBS-SSS得分,但改善了膨胀.
- 膨胀改善与减少硫化生产细菌相关.
- 在这个IBS患者队列中,FMT是安全的,并且耐受良好.
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