低值抑郁症状对认知功能和双相情感障碍的外围生物标志物的影响
Kubra Sogut1, Yasemin Gorgulu1, Orkide Palabiyik2
1Department of Psychiatry, School of Medicine, Trakya University, Edirne, Turkey.
Nordic journal of psychiatry
|September 5, 2023
概括
与健康对照组相比,双相情感障碍 (BD) 患者的认知功能较差,即使是在euthymia期间. 低于值的抑郁症 (SD) 进一步损害了认知能力,这与较高的C反应蛋白 (CRP) 水平有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 生物化学 生物化学
背景情况:
- 双极性障碍 (BD) 显著影响患者的功能能力.
- 了解导致BD患者功能障碍的因素至关重要.
研究的目的:
- 与对照人群相比,研究euthymic BD患者的认知表现差异.
- 探索低值抑郁症 (SD) 对BD认知的影响.
- 检查认知功能,血清生物标志物和BD中的临床状态之间的关系.
主要方法:
- 93名高血压的BD患者 (49名患有SD,44名没有SD) 和48名健康对照进行了认知评估 (Stroop,CVLT,Digit-Span,CWAT,Clock Drawing).
- 在BD患者中测量了血清BDNF,,酸,白细胞,CRP,TSH和维生素B12水平.
- 低值抑郁症 (SD) 被定义为HDRS得分在4到8之间.
主要成果:
- 患有BD患者的认知表现明显低于对照组 (p < 0.001).
- 与没有SD的患者相比,SD患者的注意力,工作记忆和Stroop表现受损 (p <0.05).
- 在BD患者和对照人群之间没有观察到血清BDNF水平的显著差异.
结论:
- 患有SD的EuthymicBD患者的认知功能比没有SD的患者差.
- 在BD中,认知缺陷与血清C反应蛋白 (CRP) 水平升高有关.
- 血清BDNF水平并不能将BD患者与对照患者区分开来.
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