在老年人减肥试验中应用D3 - creatine肌肉质量评估工具:试点研究
Kristen M Beavers1, Allison E Avery1, Mahalakshmi Shankaran2
1Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina, USA.
Journal of cachexia, sarcopenia and muscle
|September 5, 2023
概括
老年人减肥保留了骨肌肉质量,通过D3-肌酸 (D3 Cr) 稀释测量,尽管其他身体成分指标的下降. 在6个月的干预期间,肌肉功能和力量也保持不变.
科学领域:
- 老年学是一门学科.
- 营养科学 营养科学
- 运动生理学 运动生理学
背景情况:
- 双能量X射线吸收计 (DXA) 通常用于减肥 (WL) 试验,以估计肌肉质量,假设它反映肌肉质量.
- D3-肌酸 (D3 Cr) 稀释方法提供了对全身骨肌肉质量的直接测量,这在老年人WL研究中以前没有应用.
研究的目的:
- 为了评估D3 Cr肌肉质量的变化和变化,在经历有意减肥的老年人中进行评估.
- 为了将D3 Cr肌肉质量的变化与其他身体组成测量和肌肉功能/力量指标相关联.
主要方法:
- 利用了INVEST在骨健康试验 (NCT04076618) 的数据,这是一项为期12个月的关于肥胖老年人骨健康干预的RCT.
- 24名参与者的样本接受了基线和6个月的评估,包括D3 Cr剂量,DXA,计算机断层扫描和功能测试 (步行,爬楼梯,力量).
主要成果:
- 参与者 (平均年龄68.0岁,BMI33.8公斤/米2) 在6个月内显著减肥 (-10.3公斤).
- 虽然DXA和CT测量身体组成显著下降,但D3 Cr肌肉质量保持稳定 (+0.5公斤).
- 只有握力在肌肉功能和力量测试中显著增加 (+2.5公斤).
结论:
- 老年人有意减肥与保存的骨肌肉质量 (D3 Cr) 和保持的肌肉功能/力量有关,尽管其他生物成像指标下降.
- 进一步的分析将根据母试验治疗组分配 (抵抗训练与加权背心) 探索这些结果.
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