在基于免疫疗法的组合治疗的年龄中进行细胞还原性切除术
Sang Hun Song1, Sangchul Lee1,2
1Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.
Investigative and clinical urology
|September 5, 2023
概括
细胞还原性切除术 (CN) 可能有利于选择患有转移性细胞癌 (RCC) 的患者,如果与免疫疗法相结合,尽管之前的试验存在争议. 现实世界的数据表明,CN在先进的RCC治疗策略中可能发挥作用.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 手术瘤学手术瘤学
背景情况:
- 从历史上看,转移性细胞癌 (RCC) 的预后很差.
- 免疫疗法已经改变了先进的RCC治疗方法,超过了向疗法.
- 细胞还原性切除术 (CN) 在转移性RCC中的作用仍然存在争议,因为试验结果相互矛盾.
研究的目的:
- 审查关于细胞还原性切除术 (CN) 对转移性细胞癌 (RCC) 的作用的现代见解.
- 专注于在接受或预期接受基于免疫检查点抑制剂组合免疫治疗的患者中使用CN的潜在益处.
主要方法:
- 审查当代医学文献和现实世界的研究.
- 在现代全身疗法,特别是免疫治疗的背景下,分析关于细胞还原性切除术的证据.
主要成果:
- 尽管CARMENA和SURTIME试验的结果是负面的,但最近的现实数据表明,CN可能会对瘤有好处.
- 在接受或等待免疫治疗的转移性RCC患者中,CN可能有利.
- 潜在的益处超出了症状控制范围,包括瘤学结果.
结论:
- 细胞还原性切除术 (CN) 仍可能在某些转移性细胞癌 (RCC) 患者中发挥有价值的作用.
- 结合CN与新型免疫疗法的结合需要进一步研究先进的RCC.
- 现实世界的证据支持在转移性RCC的不断变化的治疗环境中重新考虑CN的作用.
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