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在接受精子冷保存的癌症患者中,精子质量和精子DNA碎片化

Seung-Hun Song¹, Tae Ho Lee¹, Young Sun Her²

¹Department of Urology, CHA Fertility Center Gangnam, CHA Gangnam Medical Center, CHA University, Seoul, Korea.

Investigative and clinical urology

|September 5, 2023

概括

与对照组相比,接受精子储存的癌症患者的精液质量较低. 在化疗前,精子DNA碎片化没有显著差异,支持癌症治疗前用于生育保护的精子储存.

科学领域:

生殖医学生殖医学
在瘤学瘤学.
遗传学是一个遗传学.

背景情况:

癌症诊断及其治疗方法可能会影响男性生育能力.
精子冷保存是癌症诊断的男性的生育能力保护的关键选择.
在治疗前评估精液质量和精子DNA完整性对于生育保护策略至关重要.

研究的目的:

为了比较癌症患者和接受精子冷保存的对照组之间的精液质量和精子DNA碎片化.
评估癌症和治疗前因素对精子参数的影响.

主要方法:

预计将132名男性 (65名癌症患者,67名对照人) 招募用于冷保存精子.
对精液量,精子度,运动性和DNA碎片化指数 (DFI) 的分析.
在癌症患者和对照者之间比较精子质量和DFI.

主要成果:

与对照组相比,癌症患者的精子度,总运动率和渐进运动率显著降低.
精子DNA碎片化指数 (DFI) 在癌症患者 (24.32%±15.69%) 和对照组 (19.11%±11.63%) 中显著更高.
在排除接受化疗的患者后,DFI没有显著差异,而癌症患者的其他精子参数仍然较低.

结论:

与对照人群相比,癌症患者的精液质量下降.
与对照人群相比,在化疗前的癌症患者中,精子DNA碎片化没有显著差异.
在性腺毒性化疗前储存精子是所有计划癌症治疗的男性推的标准生育保护方法.

关键词:

在DNA碎片化过程中,DNA碎片化.新生体新生体新生体精液的保存精液的保存

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