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恶性瘤大脑转移中的脂质代谢:重编程和治疗潜力

Yan-Jie Cheng^1,2, Fan Fan¹, Zhong Zhang¹

¹Department of Oncology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu, People's Republic of China.

Expert opinion on therapeutic targets

|September 5, 2023

概括

脂质代谢重编程对于大脑转移的发展至关重要. 针对这些代谢途径为来自肺癌,乳腺癌和黑色素瘤癌的脑转移提供了有希望的治疗策略.

科学领域:

在瘤学瘤学.
代谢研究研究代谢研究
神经科学是一个神经科学.

背景情况:

大脑转移意味着晚期癌症,死亡率高.
代谢变化,特别是脂质重编程,是癌症进展的关键.
了解大脑转移中的脂质变化对于治疗至关重要.

研究的目的:

审查肺,乳腺和黑色素瘤的大脑转移中的脂质代谢变化.
确定脂质代谢重编程在大脑转移中的新型作用.
评估脂质代谢作为大脑转移的潜在治疗点.

主要方法:

临床和基础研究的综合文献综述.
在PubMed,Embase,Scopus和ClinicalTrials.gov (1990-2022) 搜索了这些网站.
专注于脑转移中的脂质表达和活性.

主要成果:

脂质代谢重编程涉及新的合成,吸收,储存和膜重塑.
瘤与大脑微环境之间的代谢相互作用是重要的.
确定了脂质代谢在大脑转移中的新作用和治疗潜力.

结论:

脂质代谢是大脑转移发育的核心参与者.
在将临床前发现转化为临床应用方面仍然存在挑战.
准脂质代谢是通过药物和饮食来治疗特定器官的大脑转移的一个有希望的途径.

关键词:

大脑转移的转移.在新的脂质生成中.脂肪酸合成酶是一种脂肪酸.脂质新陈代谢脂质新陈代谢恶性瘤是一种恶性瘤.膜脂质改造膜脂质改造微观环境是一个微观环境.

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