怀孕期间的寨卡病毒查:从查计划和分娩后后续分析 (2016-2022) 中得出的结果和经验教训 (2016-2022)
Andrés Martínez-Arias1, Lluís Valerio2, Sílvia Roure-Díez2,3
1Consorci Corporació Sanitària Parc Taulí, Emergency Service, Universitat Autònoma de Barcelona, Sabadell, Catalonia, Spain.
Birth defects research
|September 5, 2023
概括
这项针对孕妇的寨卡病毒查计划是昂贵的,并且有很多不确定的结果. 应重点关注早期产妇护理,特别是移民妇女,以及简单的查方法.
科学领域:
- 孕产妇和胎儿的医学
- 传染病流行病学传染病流行病学
- 公共卫生查计划 公共卫生查计划
背景情况:
- 寨卡病毒 (ZIKV) 对孕妇和胎儿构成风险.
- 对暴露于ZIKV的无症状孕妇进行查对于早期检测和管理至关重要.
- 现有的查协议可能在成本效益和结果解释方面存在局限性.
研究的目的:
- 评估Zika病毒查计划对暴露于病毒的无症状孕妇的有效性和结果.
- 分析这个群体的社会人口统计数据,血清学结果和超声检查结果.
- 评估ZIKV暴露,血清学概况和胎儿形之间的关联.
主要方法:
- 分析了在2016-2019年期间招募的406名无症状ZIKV暴露孕妇的数据.
- 包括社会人口统计数据,超声波结果和血清学测试 (IgM,IgG,PRNT).
- 统计分析以确定ZIKV风险概况和胎儿形之间的关联.
主要成果:
- 83.2%的患者具有低风险的ZIKV血清概况,3.0%的患者具有高风险,13.7%的患者具有不确定的风险.
- 胎儿形发生在9.3%的新生儿中,与高风险ZIKV血清学概况相关 (25.0%对1.6%).
- 两名高风险型号的新生儿患有小头;没有产后发育异常与母亲的ZIKV暴露有关.
结论:
- 齐克病毒查计划是昂贵的,具有很高的不确定的结果率,提供有限的决策价值.
- 建议优先考虑早期的常规产妇护理,特别是对于移民妇女.
- 建议采用简化查方案,包括ZIKV-PCR或IgM测试,并对阳性结果或超声波异常进行转诊.
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