患有COVID-19的患者的肠道微生物群在小鼠中引起变化,类似于COVID后症状
Viviani Mendes de Almeida1, Daiane F Engel2, Mayra F Ricci1
1Laboratory of Microbiota and Immunomodulation - Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil.
Gut microbes
|September 5, 2023
概括
长期的COVID会影响肠道微生物群,增加抗生素耐药性的细菌,减少有益的短链脂肪酸. 这种失生症有助于肺炎和认知问题,表明肠道微生物群作为COVID后疾病的治疗点.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 冠状病毒疾病 (COVID) -19的长期后果是一个重大问题.
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染影响肠道微生物群,与COVID-19的严重程度相关.
研究的目的:
- 为了研究SARS-CoV-2感染对肠道微生物群的长期影响.
- 为了确定COVID-19后的肠道失调有助于持续的症状和并发症.
主要方法:
- 与对照人群相比,对后COVID患者肠道微生物群组成和抗生素耐药性的分析.
- 测量便短链脂肪酸 (SCFA) 的水平.
- 从COVID后受试者移植便微生物群到无菌小鼠中,随后进行肺部感染挑战和认知评估.
主要成果:
- 后COVID试验对象在肠道微生物群中表现出抗生素耐药*Enterobacteriaceae*菌株的主导地位.
- 在COVID后的个人便中观察到较低的SCFA水平.
- 移植的小鼠患有肺炎,在Klebsiella肺炎感染期间结果更差,认知能力受损.
结论:
- SARS-CoV-2 感染会导致长时间的肠道微生物群变化,这种变化在病毒清除后仍然存在.
- 在COVID-19之后的肠道失调可以直接导致COVID后的后果,包括肺炎和认知缺陷.
- 肠道微生物群是治疗长期COVID症状的潜在治疗目标.
相关概念视频
Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...


