狂犬病病毒的演变和分布从全景视图
Gen Li1, Yue Zhang1, Hong-Ling He1
1College of Veterinary Medicine, South China Agricultural University , Guangzhou, China.
Microbiology spectrum
|September 5, 2023
概括
这项研究揭示了狂犬病病毒 (RABV) 的演变和全球分布,确定了北美关键的重组热点和潜在的蝙蝠起源. 它突出了梅菲科的特点.
科学领域:
- 病毒学 病毒学
- 进化生物学 进化生物学
- 生物信息学是一种生物信息学.
背景情况:
- 狂犬病病毒 (RABV) 每年造成超过59000人死亡,主要是在发展中国家.
- 现有的RABV进化和分布的研究是分散的.
- 野生动物是全球RABV传播的重要储备.
研究的目的:
- 提供RABV演变和分布的全面概述.
- 分析植物遗传多样性,进化模式和RABVs的时空传播.
- 确定影响RABV传播和血统分歧的遗传因素.
主要方法:
- 使用多种生物信息工具对1202个全长RABV基因组进行了家族遗传学分析.
- 基于N和L基因的时空和进化速率分析.
- 识别重组事件,积极选择的氨基酸和单核酸变异.
主要成果:
- 确定了十个不同的RABV遗传分类,在亚洲-SEA,北极和中国的Cosmopolitan分类中经常进行重组.
- 有证据表明,RABV可能起源于北美蝙蝠,根的估计年龄为1,406.6 (N基因) 和1,122.7 (L基因) 年.
- 梅菲类动物 (类动物) 在物种间RABV传播中至关重要,其传播有利于基因接近的宿主.
结论:
- 这项研究提供了RABV演变和分布的全景,对于了解其全球流行病学至关重要.
- 这些发现强调了监测动物狂犬病水库中的传播动态的重要性.
- 识别遗传标记有助于了解RABV的适应性和在不同的血统和宿主中传播.
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