在萨摩亚成年人中,初潮时的年龄与心脏代谢风险之间的关联
Sakurako Oyama1,2, Rachel L Duckham3,4, Alysa Pomer5
1Yale School of Medicine, New Haven, Connecticut, USA.
概括
晚年初潮与降低高血压风险有关,但在萨摩亚妇女中增加了糖尿病和高胆固醇风险. 这突出了特定于人群的心脏代谢健康因素.
科学领域:
- 生殖健康和流行病学
- 心脏代谢疾病的危险因素 心脏代谢疾病的危险因素
- 全球健康差异的差异
背景情况:
- 新出现的证据将初潮的早期年龄与心脏代谢发病率和死亡率的增加联系在一起.
- 太平洋岛屿的全球高肥胖率需要对当地心脏代谢风险因素进行研究.
- 初潮时的年龄与心脏代谢风险之间的关联在萨摩亚人群中仍未得到充分研究.
研究的目的:
- 为了研究初潮时的年龄和萨摩亚成年人的心脏代谢风险指标之间的关系.
- 评估与肥胖,高血压,糖尿病,失脂症和代谢综合征的关联.
- 检查与持续测量脂肪,血压,胰岛素抵抗和血清脂质的联系.
主要方法:
- 分析了在萨摩亚 (2017-2019) 进行的Soifua Manuia研究中的285名成年参与者 (32-72岁) 的数据.
- 后勤回归模型用于估计心脏代谢疾病的几率,每年增加初潮时的年龄.
- 线性回归模型用于评估与持续脂肪,血压和脂质测量的关联.
主要成果:
- 初潮时的平均年龄为14岁 (IQR: 2).
- 初潮时的年龄每增加一年都与糖尿病的几率增加21% (OR=1.21,p=.044) 和总胆固醇升高的趋势 (OR=1.18,p=.081) 相联系.
- 初潮时每增加一年的年龄与瘦肉量 (-1.60公斤,p=.002) 和无脂肪质量 (-1.56公斤,p=.003) 的减少相关.
结论:
- 初潮时的年龄与心脏代谢风险的关联似乎是特定于人群的,受营养和流行病学背景的影响.
- 需要进一步的前性研究来阐明早期生命暴露的作用,包括儿童肥胖,初潮时间和随后的心脏代谢健康.
- 研究结果强调,需要针对特定环境的公共卫生战略,以解决太平洋岛屿人口的心脏代谢风险.
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