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在接受-葡萄糖共运输体2抑制剂治疗的患者中,优糖性糖尿病酸性酸症
Daniel B Hammond1, Claire C Ingram
1Daniel B. Hammond is director of admissions and recruitment for the PA program at the University of California San Diego. Claire C. Ingram is an instructor in the Division of Endocrinology, Metabolism, and Diabetes and the Section of Maternal-Fetal Medicine at the University of Colorado School of Medicine. The authors have disclosed no potential conflicts of interest, financial or otherwise.
-葡萄糖共运输体2 (SGLT2) 抑制剂是增加葡萄糖分泌的新型2型糖尿病药物. 它们提供了超出血糖控制的好处,但可能会导致罕见的严重副作用,如euglycemic糖尿病酸症.
科学领域:
- 药理学 药理学 是一个学科.
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- -葡萄糖共运输体2 (SGLT2) 抑制剂代表了治疗2型糖尿病的新型药物.
- 这些药物独特地促进尿液中的葡萄糖分泌,使其与其他抗糖尿病药物区别开来.
- 在患有心血管疾病,脏疾病和心力衰竭的患者中,SGLT2抑制剂已经证明有好处.
研究的目的:
- 讨论euglycemic糖尿病酸性脂肪酸症,与SGLT2抑制剂相关的一种危及生命的不良反应.
- 为需要手术的SGLT2抑制剂患者提供管理建议.
主要方法:
- 对SGLT2抑制剂药理学和临床试验数据的文献综述.
- 对报告的euglycemic糖尿病酸性酸症病例的分析.
- 综合现行指导方针和专家建议,关于外科手术期间的管理.
主要成果:
- SGLT2 抑制剂通过增加尿路葡萄糖分泌来降低血糖.
- 益处扩展到特定患者群体的心血管和脏保护.
- 优糖性糖尿病酸性酸症是一种关键的,尽管罕见,但需要迅速识别和管理的不良事件.
结论:
- SGLT2 抑制剂是2 型糖尿病的有价值的药物,特别是伴随性疾病.
- 意识到euglycemic糖尿病酸症对于安全的处方至关重要.
- 术后管理策略对于减轻手术患者的风险至关重要.
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