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设计聚合物用于软骨吸收:结构和摩尔质量的影响

Jue Gong¹, Jordan Nhan², Jean-Philippe St-Pierre²

¹Department of Chemistry, The University of Western Ontario, 1151 Richmond St., London, Ontario, N6A 5B7, Canada. egillie@uwo.ca.

Journal of materials chemistry. B

|September 5, 2023

概括

研究人员开发了用于骨关节炎药物输送的新型聚合物. 线性结构显示出比分支结构更好的软骨透和保留,通过调整聚合物大小来平衡吸收和细胞毒性来实现最佳的药物递送.

科学领域:

生物材料科学生物材料科学
药物输送系统药物输送系统
骨关节炎研究骨关节炎研究

背景情况:

骨关节炎 (OA) 涉及到软骨的分解,目前没有疾病修饰治疗.
药物输送到无血管软骨是具有挑战性的,因为其密集的矩阵.
阴离子载体显示出潜力,但宏分子架构效应尚未被探索.

研究的目的:

合成和评估具有不同架构 (线性,4臂,8臂) 和聚合度 (DP) 的聚合物,用于软骨药物输送.
评估牛关节软骨中聚酸的吸收,保留和细胞毒性.
为了确定最佳的聚化设计,以提高软骨透和治疗潜力.

主要方法:

基于HPMA-APMA的聚合物的合成,使用RAFT聚合.
在牛关节软骨扩展体中对聚酸的吸收和保留的评估.
对牛肉细胞的多化细胞毒性的评估.

主要成果:

所有合成的多聚酸都穿透了软骨.
摄入量和保留量随DP增加,但在非常高DP下降.
线性多元化显示出比分支架构更高的吸收和保留率.
较高的DP聚合体表现出更高的细胞毒性.

结论:

线性聚化结构有利于软骨矩阵结合.
调整聚合度对于最大限度地吸收,同时最大限度地降低状细胞毒性至关重要.
这些发现为开发有效的骨关节炎治疗方法提供了有希望的策略.

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