多巴氨基损伤模式预测了孤立的快速眼动睡眠行为障碍中的表态转换时间
Shuang Feng1,2, Jingjie Ge3,4, Shujun Zhao2
1Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China.
European journal of nuclear medicine and molecular imaging
|September 5, 2023
概括
现在可以预测单独的REM睡眠行为障碍 (iRBD) 中同核蛋白病变的转化. 全脑多巴胺损伤模式可以准确预测个体患者的表转化时间,帮助早期干预策略.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 孤立的快速眼动 (REM) 睡眠行为障碍 (iRBD) 是同核蛋白病变的前兆阶段.
- 从iRBD到同核蛋白病变的表转化时间目前无法预测.
- 早期识别具有高风险的患者的现象转换对于及时干预至关重要.
研究的目的:
- 为了研究iRBD患者的全脑多巴胺基损伤模式 (DDP).
- 分析多巴氨基损伤随着疾病进展的进展.
- 预测个人iRBD患者的转换时间到同核蛋白病变.
主要方法:
- 33名iRBD患者和20名健康对照人接受了11C-CFT-PET扫描.
- 患者被跟踪了2-10年,而表转换年被定义为基准年.
- 为了预测,使用了带有leave-one-out交叉验证的支向量机器模型.
主要成果:
- 在iRBD中,多巴胺基退行开始于临床转化前大约6年.
- 多巴氨基损伤模式在预测不同时间点的现象转换方面表现出高准确性 (AUC 0.807-0.940).
- 预测的现象转换阶段与全脑多巴胺激素水平有很强的相关性 (r = -0.740,p < 0.001).
结论:
- 全脑多巴胺损伤模式可以准确地预测个人iRBD患者的表转换时间.
- 这种预测能力可能有助于早期查患者是否患有同核蛋白病变.
- 早期识别和干预可能会改变疾病的发展轨迹.
关键词:
多巴胺损伤模式的多巴胺损伤模式.孤立的REM睡眠行为障碍定子发射断层扫描 (PET) 是一种定子发射断层扫描.预测 预测 预测合成核蛋白病变 (Synucleinopathies) 是一种同核蛋白病变.更多相关视频
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