胃肠癌患者在化疗期间运动的可行性和安全性:试点研究
Song Ee Park1,2, Du Hwan Kim2,3, Don-Kyu Kim4
1Department of Internal Medicine, Chung-Ang University Gwang-Myeong Hospital, Chung-Ang University College of Medicine, Seoul, Korea.
概括
运动干预计划 (EIP) 对于正在接受息化疗的晚期胃肠道癌症患者是可行的. 良好的遵守EIP有助于保持肌肉质量和改善生活质量,这表明运动对这一群体有好处.
科学领域:
- 在瘤学瘤学.
- 运动生理学 运动生理学
- 老年病的医生 老年病的医生
背景情况:
- 皮症对癌症患者的预后产生负面影响.
- 运动是对萨尔科佩尼亚的潜在干预措施.
- 在晚期癌症患者中,对运动有效性的证据有限.
研究的目的:
- 在接受息化疗的晚期胃肠癌患者中评估运动干预计划 (EIP) 的可行性.
- 评估EIP对肉类的影响,生活质量 (QoL) 和整体生存时间 (OS).
主要方法:
- 30名晚期胃肠道癌患者参加了为期6周的耐力和有氧运动计划.
- 患者根据能力选择了运动强度 (低,中等,高).
- 主要终点:通过遵守可行性 (>50%被认为是可以接受的). 二级终点:体重变化,肌肉质量 (骨肌肉指数 - SMI),安全性,QoL和OS.
主要成果:
- 总体遵守率为63.3%,其中53.3%实现了>80%的遵守.
- 平均SMI总体下降了-1.2cm2/m2 (-3.0%) (p=0.030). 总体上下降了 -1.2cm2/m2 (-3.0%).
- 良好合规组保持SMI (-0.5cm2/m2),而不良合规组显示显著下降 (-2.8cm2/m2,p=0.033).
- 良好合规组的生存期明显更长 (25.3个月与7.9个月,p=0.014).
- 失眠的QOL有所改善 (p=0.042);没有严重的不良事件.
结论:
- 在缓和化疗期间,运动干预计划对于晚期胃肠道癌症患者来说是可行的和安全的.
- 良好的遵守EIP与维持肌肉质量和改善QoL有关.
- 需要对晚期癌症患者的运动干预措施进行进一步的研究.
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