一种基于奇托桑的多克西纳米配方治疗化疗引起的口腔粘膜炎:一个随机,双盲,安慰剂控制的临床试验
Nazafarin Samiraninezhad1, Mostafa Rezaee2, Ahmad Gholami3
1School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Inflammopharmacology
|September 5, 2023
概括
一种新的doxepin/chitosan纳米凝有效治疗化疗诱导的口腔粘膜炎. 与标准治疗相比,这种纳米配方显著降低了疼痛和病变严重程度,为患者提供了一个有前途的替代方案.
科学领域:
- 制药科学 制药科学
- 生物材料科学 生物材料科学
- 瘤科 支持性护理
背景情况:
- 口腔粘膜炎 (OM) 是癌症化疗的常见,痛苦的副作用.
- 目前对OM的治疗方法的疗效有限,并且可能会产生副作用.
- 需要新的治疗策略来管理化疗诱导的口腔粘膜炎 (CIOM).
研究的目的:
- 开发和评估一种含有多克西的基索基纳米配方,用于治疗CIOM.
- 为了利用多克塞的止痛特性和奇托的抗微生物/生物粘合性.
- 评估纳米配方在减少OM严重性和疼痛方面的有效性.
主要方法:
- 使用离子凝制造了一种多克西/奇托桑纳米凝 (CN+DOX).
- 60名CIOM患者被随机分配到四组,接受不同治疗14天.
- 使用国家癌症研究所 (NCI),世界卫生组织 (WHO),世界护理临床与研究会议 (WCCNR) 指数和视觉模拟尺度 (VAS) 来评估口腔病变的严重程度.
主要成果:
- CN+DOX配方呈现出均的球形形状,平均尺寸为47.93nm.
- 与对照组相比,CN+DOX在第3天显著降低了WHO,WCCNR和VAS得分.
- 到第14天,CN+DOX与对照组相比,NCI得分明显下降.
结论:
- 基于奇托桑的多克西纳米配方是一种潜在的有效治疗口腔粘膜炎的方法.
- 这种纳米配方为CIOM的传统治疗提供了一个有希望的替代方案.
- 需要进一步的临床研究来证实其治疗潜力.
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