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大脑细分方法对区域代谢量化的影响在F-FDG PET/MR分析中

Yi Shan^1,2, Shao-Zhen Yan^1,2, Zhe Wang³

¹Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, #45 Changchunjie, Xicheng District, Beijing, 100053, China.

EJNMMI research

|September 5, 2023

概括

通过比较用于定量PET/MR分析的大脑细分方法,可以发现,虽然大多数方法显示出强烈的相关性,但基于AI的方法提供了更高的效率和准确性,特别是在特定的大脑区域,如基底和大脑皮层.

科学领域:

神经成像是一种神经成像.
医学物理医学物理
放射化学放射化学是指辐射化学.

背景情况:

量化PET数据分析对于研究小脑结构至关重要.
集成的PET/MR系统提供结构MRI和分子PET图像的精确空间和时间对齐.
临床工作流程往往省略个人MRI扫描,以方便PET分析,影响细分精度.

研究的目的:

为了比较和评估各种大脑细分策略之间的相关性,一致性和差异.
在18F-FDG PET/MR分析中评估细分方法对大脑代谢量化的影响.
为临床应用验证人工智能辅助细分方法的效率和准确性.

主要方法:

分段化策略的比较:有/没有MRI注册和基于图谱的与基于个体的算法.
评估人工智能 (AI) 辅助的细分方法.
对18F-FDG PET/MR脑代谢数据进行定量分析.

主要成果:

所有细分方法都显示出强烈的相关性 (r=0.932到0.999).
由于主体和大脑区域的差异超过了细分方法的差异.
基于人工智能的方法显示高相关性 (r=0.998-0.999) 和ICC与FreeSurfer,大大减少处理时间从每人8.13小时到57秒.

结论:

分段方法可以影响大脑代谢量化,特别是在基底和特定的大脑皮层.
基于AI的细分显著提高了效率和性能.
人工智能辅助的方法被推用于临床应用,因为它们的准确性和速度提高了.

关键词:

人工智能的人工智能是人工智能.磁共振成像技术磁共振成像技术代谢过程中的代谢.定子发射断层扫描 (PET) 是一种定子发射断层扫描.

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Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...