患有子宫内膜癌的老年妇女的身体功能变化,有或没有辅助治疗
Allison M Quick1, Eric McLaughlin2, Jessica L Krok Schoen3,4
1Department of Radiation Oncology, The Ohio State University Medical Center, Columbus, OH, USA. allison.quick@osumc.edu.
Journal of cancer survivorship : research and practice
|September 5, 2023
概括
接受辅助治疗的子宫内膜癌 (EC) 的老年妇女在身体功能 (PF) 中出现了较大的下降. 特别是化疗与EC幸存者的更显著的功能变化有关.
科学领域:
- 老年学是一门学科.
- 在瘤学瘤学.
- 癌症的生存率 癌症的生存率
背景情况:
- 子宫内膜癌 (EC) 显著影响老年妇女的生活质量.
- 辅助疗法,包括化疗和放射治疗,是EC的常见治疗方法.
- 了解这些治疗对身体功能 (PF) 的长期影响对于患者护理至关重要.
研究的目的:
- 评估被诊断患有子宫内膜癌 (EC) 的老年妇女身体功能 (PF) 的变化.
- 为了比较接受辅助治疗的EC患者与没有接受辅助治疗的患者的PF变化.
- 为了确定与更大的身体功能下降相关的特定辅助疗法.
主要方法:
- 这项研究分析了来自妇女健康倡议生命和癌症后寿命队列的数据.
- 使用RAND-36仪器对70岁及以上患有EC的女性进行身体功能 (PF) 评估.
- 统计分析包括威尔科克森等级和值测试和多变量中位数回归,以比较治疗组之间的PF变化.
主要成果:
- 总共包括287名患有EC的妇女;150人没有接受辅助治疗,137人接受了辅助治疗.
- 接受辅助治疗的妇女在PF中出现了统计学上显著的更大的中位数百分比下降 (-5.9%) 与没有接受辅助治疗的妇女 (0%) 相比.
- 虽然在多变量调整后,化疗在统计学上没有显著意义,但与单独照射或联合化疗照射相比,化疗与更大的中位数PF下降有关 (-13.8%).
结论:
- 接受辅助治疗,特别是化疗的EC的老年妇女在身体功能 (PF) 中经历了更明显的变化.
- 这些发现表明,化疗和/或放射治疗可能导致EC幸存者的功能下降.
- 加强支持性护理策略可能是必要的,以帮助减轻老年EC幸存者的功能衰退.
关键词:
辅助疗法是一种辅助疗法.化疗 化疗是一种化学疗法.这是子宫内膜癌的癌症.外部光束辐射的辐射.功能性衰退 功能性衰退功能状态 功能状态莉莉亚兰 (Lilac) 是一个红色的.年龄较大的女性.兰德36号公司辐射辐射辐射的辐射是什么阴道支臂疗法 阴道支臂疗法在WHI中,WHI是什么?妇女健康倡议妇女健康倡议更多相关视频
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