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Updated: Jul 17, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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Published on: July 17, 2020

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从MD模拟中揭示PTPN11 SH2域中的Allostery

Massimiliano Anselmi1, Jochen S Hub2

  • 1Theoretical Physics and Center for Biophysics, Saarland University, Saarbrücken, Germany. massimiliano.anselmi@uni-saarland.de.

Methods in molecular biology (Clifton, N.J.)
|September 5, 2023
PubMed
概括

本研究介绍了一种主要成分分析 (PCA) 方法,用于分析Src-homology 2 (SH2) 域结构. 该方法揭示了SHP2的N-SH2和C-SH2域之间的明显的结构动态,反映了它们独特的功能作用.

关键词:
所有的法规都是单一的.分子动力学模拟的模拟.酸酶是一种酸酶.主要组件分析的主要组件分析.蛋白质动力学 蛋白质动力学蛋白质的功能蛋白质的功能这就是SH2域名.

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