利用霍夫迈斯特效应,诱导非离子超分子聚合物的水凝化到治疗储存中
1Department of Chemical and Biomolecular Engineering and Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Angewandte Chemie (International ed. in English)
|September 5, 2023
概括
研究人员开发了一种新的盐触发方法,用于形成非离子超分子水凝. 这些含有抗癌前期药物的水凝显示出持续治疗和降低免疫反应的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 超分子化学 超分子化学
- 药物运输 药物运输 药物运输
背景情况:
- 对于治疗性植入物来说,非性水凝具有较低的免疫性.
- 在生理条件下,非离子超分子凝在现场形成仍然具有挑战性.
研究的目的:
- 报告发现非离子超分子聚合物 (SPs) 的盐触发水凝.
- 通过霍夫迈斯特效应研究前期药物水凝器 (SAPH) 通过霍夫迈斯特效应对潜在的抗癌药物递送的自我组装.
主要方法:
- 设计的自组装前期药物水凝器 (SAPH) 配备SN-38单元和橄乙烯糖醇 (OEG) 分段.
- 使用酸盐来触发水溶液中的非离子SPs的水化.
- 采用1H NMR光谱来研究盐诱导的水凝化机制.
主要成果:
- 酸盐破坏了水以太键,改变了SPs的水化外.
- 添加盐促进了关联性相互作用,导致SAPH丝的透到3D水凝网络中.
- 形成的水凝显示出强大的抗癌剂SN-38.8的持续释放.
结论:
- 霍夫迈斯特效应提供了一种可行的策略,用于在现场形成非离子超分子水凝.
- 这些盐触发的水凝对局部和持续的抗癌治疗药物提供有希望.
- 开发的水凝系统最大限度地降低了免疫性,提高了其长期植入的潜力.
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