使用无监督学习算法在门诊患者中定义通常的口腔温度范围
Catherine Ley1, Frederik Heath2,3, Trevor Hastie4,5
1Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.
正常的口腔温度因年龄,性别和一天中的时间等个人因素而异. 这项研究建立了个性化的正常温度范围,改善了超出单一标准值的临床评估.
科学领域:
- 医学科学 医学科学 医学科学
- 临床研究 临床研究
- 生理学 生理学 生理学
背景情况:
- 口腔温度评估在医疗实践中很常见,但正常范围的定义很差.
- 确定精确的正常温度范围对于准确的临床解释至关重要.
研究的目的:
- 根据年龄,性别,身高,体重和一天中的时间来确定正常的口腔温度范围.
- 为成人门诊患者制定个性化的正常温度范围.
主要方法:
- 一项横截面研究分析了超过60万例门诊患者与温度测量的接触.
- 该LIMIT算法过了遭遇,以排除影响温度分布的诊断.
- 混合效应建模确定了影响正常口腔温度的因素.
主要成果:
- 超过35%的遭遇被排除在外;传染病和2型糖尿病是主要原因.
- 个别因素 (年龄,性别,身高,体重,一天的时间) 解释了高达25.52%的温度变化.
- 平均正常口腔温度没有达到37°C;上99百分位数变化很大 (36.81°C至37.88°C).
结论:
- 正常的口腔温度表现出基于个体特征的预期变化.
- 可以建立个性化的正常温度范围,提高临床效用.
- 需要进一步的研究来确定温度在这些既定范围之外的临床意义.
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