在儿科患者中从豆油基脂类乳液转换为混合脂类乳液
Krista L Haines1,2, Tetsu Ohnuma2,3, Chi Dang Hornik4
1Division of Trauma and Critical Care and Acute Care Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina.
JAMA network open
|September 5, 2023
概括
在重症儿科患者中,切换到混合脂类乳液 (4-OLE) 显著减少了住院时间和尿路感染风险. 这种大豆瘦的策略是安全有效的,用于儿科亲肠道营养.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 营养支持 营养支持
- 脂质乳液的药理学 脂质乳液的药理学
背景情况:
- 重症儿童往往需要通过肠道营养 (PN).
- 与传统的以大豆油为基础的脂质乳液相比,混合脂质乳液 (LE) 可能提供更好的结果.
- 在儿科PN中正在探索减少大豆油的策略.
研究的目的:
- 研究医院范围内的转换为混合脂类乳液 (4-OLE) 与接受PN的儿科患者的临床结果之间的关联.
- 为了比较实施4-OLE之前和之后的结果.
主要方法:
- 美国学术推中心的回顾性队列研究.
- 包括从2016年5月到2019年9月需要PN的儿科患者 (1个月至17岁).
- 使用多变量回归,比较在切换前接受Intralipid (IL) 和切换后使用4-OLE的患者之间的结局.
主要成果:
- 这项研究包括684名PN儿童;478名接受4-OLE,206名接受IL.
- 4-OLE组显示,所有儿童和ICU队列的住院时间 (LOS) 显著减少.
- 与IL组相比,在4-OLE组观察到尿路感染 (UTI) 的风险降低.
结论:
- 在儿科PN患者中切换到4-OLE配方与医院LOS的显著减少有关.
- 这些发现表明,采用4-OLE的豆瘦策略对于需要PN的儿科患者来说是可行的,安全的和有益的.
- 这种方法可能会在这个脆弱人群中改善临床结果.
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