女性生殖因素和子宫内膜癌风险
Ryoko Katagiri1,2, Motoki Iwasaki1,3, Sarah Krull Abe4
1Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
JAMA network open
|September 5, 2023
概括
这项研究发现,较晚的初潮,更早的更年期和更多的分娩与亚洲女性患子宫内膜癌的风险较低有关. 这些发现突出了影响癌症发展的关键生殖因素.
科学领域:
- 生殖流行病学 生殖流行病学
- 妇科瘤学 妇科瘤学
背景情况:
- 有证据表明生殖因素与子宫内膜癌风险之间存在联系.
- 关于这个话题的前性研究主要集中在非亚洲人群上.
研究的目的:
- 研究各种生殖因素与亚洲女性患子宫内膜癌的风险之间的关联.
- 为亚洲人口群体提供关于子宫内膜癌病因学的见解.
主要方法:
- 在亚洲队列联盟 (Asia Cohort Consortium) 中,对来自13项前性队列研究的个人参与者数据进行了聚合分析.
- 涉及332,625名亚洲女性,在16.5年的平均随访期间发现了1005例子宫内膜癌病例.
- 考克斯的比例危险模型被用来计算基于生殖因素的子宫内膜癌风险的危险比率 (HRs) 和95%置信区间 (CI).
主要成果:
- 更多的分娩显示出与降低子宫内膜癌风险的剂量反应相关性 (例如,≥5次分娩与无产妇相比:HR,0.37).
- 晚期初潮 (≥17年) 与早期初潮 (<13年) 相比,风险降低 (HR,0.64).
- 与早期更年期 (<45岁) 相比,晚期更年期 (≥55岁) 与风险增加有关 (HR,2.84).
结论:
- 晚期初潮,分娩次数增加和更年期早期显著与子宫内膜癌风险降低有关.
- 来自亚洲女性的大型综合研究的这些发现加强了生殖特征和子宫内膜癌之间的关系.
- 这项研究为全球对子宫内膜癌风险因素的理解增加了来自亚洲人口的关键数据.
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