疫苗和多发性硬化症发作住院的风险
Lamiae Grimaldi1,2,3, Caroline Papeix4,5, Yann Hamon6
1Department of Pharmacology, Hospital Group Paris-Saclay, Assistance Publique-Hôpitaux de Paris, Paris, France.
JAMA neurology
|September 5, 2023
概括
这项研究发现疫苗接种和多发性硬化症 (MS) 爆发需要住院治疗之间没有联系. 建议继续进行研究,以在各种疫苗类型中证实这些发现.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 关于疫苗接种与多发性硬化症 (MS) 恶化之间存在关联的科学数据有限.
- 疫苗接种对公共卫生至关重要,需要明确其在多发性硬化症患者中的安全性.
研究的目的:
- 调查在被诊断患有MS的个体接种疫苗后严重MS发作住院的风险.
主要方法:
- 法国的一项全国性队列研究分析了来自国家健康数据库系统 (2007-2017) 的数据.
- 一个嵌套病例交叉分析比较了疫苗接种前和后的MS爆发率 (白喉,结节病,脊髓灰质炎,百日咳,Hemophilus influenzae;流感;肺炎球菌).
主要成果:
- 该研究包括106523名多发性硬化症患者,其中35265人因发作住院治疗.
- 在接种疫苗和住院治疗MS发作之间没有发现统计学意义上的关联 (所有疫苗:AOR 1.00;95% CI,0.92-1.09).
- 像DTPPHi (AOR 0.95) 和流感 (AOR 0.98) 等特定疫苗没有增加风险,而肺炎球菌疫苗显示边缘风险增加 (AOR 1.20;95% CI,0.94-1.55).
结论:
- 这项法国全国性的研究发现,没有证据表明疫苗接种与MS爆发入院的风险增加有关.
- 需要进一步的研究来探索与不同疫苗亚型的潜在关联.
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