iCVS-从床边可用的生理信号推断出心血管隐藏状态
Neta Ravid Tannenbaum1,2, Omer Gottesman3, Azadeh Assadi4,5
1Faculty of Data and Decision Science, Technion, Haifa Israel.
PLoS computational biology
|September 5, 2023
概括
我们开发了iCVS,这是一个动态模型,可以从血压数据中推断出隐藏的心血管状态. 这个工具通过识别出血和心脏功能障碍等疾病来帮助重症监护中的临床医生.
科学领域:
- 重症监护医药重症监护医药重症监护医药重症监护医药
- 生理学建模 生理学建模
- 心血管动力学的动态
背景情况:
- 从有限的数据中推断患者的生理状态是重症监护中的一个关键挑战.
- 临床医生使用各种可观察因素估计隐藏的心血管变量,这是一个复杂和专业知识驱动的过程.
- 机械动态模型提供可解释和预测的临床决策支持.
研究的目的:
- 开发iCVS,一种简单的,机械的动态模型,用于推断隐藏的心血管状态.
- 创建一个工具,用于在重症监护室 (ICU) 的病床部署和回顾性分析.
- 评估iCVS在重症儿童中识别心血管功能障碍的能力.
主要方法:
- 开发了iCVS,这是一个动态机械模型,仅使用动脉和静脉压力波形作为输入.
- 模型估计需要最小的生理参数 (年龄,体重) 并考虑自主调节.
- 利用血压信号的快速和缓慢时间尺度来增强信息提取.
主要成果:
- 该iCVS模型初步显示出识别严重疾病儿童出血,分布状态和心脏功能障碍的能力.
- 该模型只使用压力波形成功推断出隐藏的心血管状态.
- 该模型的动态演变运行在临床上相关的时间尺度分钟.
结论:
- iCVS是一个有前途的工具,用于推断密集护理机构中隐藏的心血管状态.
- 该模型的可解释性和预测能力可以支持临床决策.
- iCVS有潜力用于心血管不稳定性的病床应用和研究.
相关概念视频
01:30Pulse rhythm
832
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
832
01:30Equipments Used To Measure Blood Pressure
1.1K
Direct Method
This invasive approach involves cannulating a peripheral artery. During each cardiac contraction, pressure generates mechanical motion within the catheter, transmitted through rigid, fluid-filled tubing to a transducer. This transducer converts mechanical motion into electrical signals displayed as waveforms on a monitor. An automatic flushing system prevents blood backflow. Due to the potential risk of unexpected arterial blood loss, this method is primarily used in intensive...
This invasive approach involves cannulating a peripheral artery. During each cardiac contraction, pressure generates mechanical motion within the catheter, transmitted through rigid, fluid-filled tubing to a transducer. This transducer converts mechanical motion into electrical signals displayed as waveforms on a monitor. An automatic flushing system prevents blood backflow. Due to the potential risk of unexpected arterial blood loss, this method is primarily used in intensive...
1.1K
01:29Electrocardiogram
2.5K
An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
2.5K
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
201
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
201
01:23Assessment of the Cardiovascular System I: Subjective Data
366
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
366
01:25Correlation between ECG and Cardiac Cycle
6.6K
The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
6.6K