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神经性厌食症和上腺激素:一个系统的审查和元分析
Subhanudh Thavaraputta1,2, Patompong Ungprasert3, Selma F Witchel4
1Neuroendocrinology Unit, Division of Endocrinology and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States.
European journal of endocrinology
|September 5, 2023
概括
患有神经性厌食症的女性表现出皮质醇水平升高和脱水氨硫酸 (DHEA-S) 和的降低. 这些荷尔蒙变化对于在低体重个体中诊断上腺轴障碍至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 神经性厌食症是一种精神疾病,其特点是自我诱导的负能量平衡.
- 饥饿和低体重会引发荷尔蒙适应,特别是影响上腺皮质荷尔蒙.
- 了解这些激素变化对于准确的诊断和管理至关重要.
研究的目的:
- 系统地审查和综合有关神经性厌食症患者上腺皮质激素水平的数据.
- 为了比较精神性厌食症患者和健康的正常体重对照者之间的激素水平.
主要方法:
- 在MEDLINE和EMBASE进行了全面的文献搜索,截至2021年10月.
- 包括报告关于脱水氨 (DHEA),DHEA-S,孕激素,皮质醇,和其他上腺皮质激素的研究.
- 使用随机效应模型进行了元分析,以计算每个激素的集成平均差异 (MD).
主要成果:
- 该审查包括101项研究,涉及超过2500名患有神经性厌食症的女性.
- 在各种测量方法 (血清,尿液,甲抑制试验) 中,神经性厌食症患者的皮质醇水平显著更高.
- 在神经厌食症患者中,血清中平均总和脱氨酸硫酸 (DHEA-S) 水平显著降低.
结论:
- 与健康对照人群相比,神经性厌食症与皮质醇升高和DHEA-S和水平降低有关.
- 这些荷尔蒙特征对于评估潜在的上腺轴障碍至关重要,如库辛综合征,在体重不足的女性.
- 这些发现强调了厌食症的神经内分泌失调的特征.
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