2'-修改型蒂米丁与生物对角环或悉诺因作为无铜后合成功能化化学合成的寡核酸的构建块

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Updated: Jul 17, 2025

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
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Alexandra Bristiel1,2, Manon Cadinot2, Mathieu Pizzonero2

  • 1Université Paris-Saclay, CNRS, Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), UMR 8182, 91405, Orsay, France.

Bioconjugate chemistry
|September 5, 2023
PubMed
概括

研究人员开发了用于制造改性寡核酸 (ONs) 的新建构件. 这些新型单体使ONs的无痕后合成标记能够使用生物对等反应用于化学生物学和药物开发.

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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