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Updated: Jul 17, 2025

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
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Published on: May 20, 2020

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针对EGFR Exon 20插入 (Ex20ins) 突变的结构机制和抑制剂

Hao Chen1, Shiliang Hu1, Adam V Patterson2,3

  • 1International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, 855 Xingye Avenue, Guangzhou 510632, China.

Journal of medicinal chemistry
|September 5, 2023
PubMed
概括

新疗法针对非小细胞肺癌 (NSCLC) 的表皮生长因子受体 (EGFR) 插入外20突变 (Ex20ins). 本研究分析了耐药性机制和抑制剂结合,以改善下一代EGFR Ex20ins治疗方法.

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