具有多层次触发药物透的智能响应纳米粒子用于瘤光化疗
Yale Yue1,2, Hejia Li3, Xinwei Wang4
1Department of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
ACS applied materials & interfaces
|September 5, 2023
概括
这项研究介绍了智能纳米粒子,这些纳米粒子通过近红外光改变尺寸. 这些响应性纳米药物增强了瘤透率,并将光热和化疗结合起来,以有效治疗癌症.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 在瘤学瘤学.
背景情况:
- 纳米医学面临着瘤透的挑战,原因是矛盾的尺寸要求.
- 较大的纳米粒子增强瘤积累,而较小的纳米粒子则透到更深层的瘤组织中.
- 需要智能响应性纳米医学系统来改善积累和透.
研究的目的:
- 开发一个由近红外 (NIR) 光触发的智能响应纳米粒子系统.
- 整合光热疗法 (PTT) 和化疗,以增强协同作用的抗瘤作用.
- 为了克服纳米医药尺寸要求对瘤治疗的局限性.
主要方法:
- 构造的温度敏感脂质体 (TSL) 封装了装载着多克索鲁比 (DOX) 的超小黑色素纳米粒子 (MNP).
- 利用NIR辐射触发纳米粒子结构变化和药物释放.
- 在4T1乳腺瘤携带的小鼠中评估了该系统的有效性.
主要成果:
- 围血管瘤细胞的NIR辐射诱导的纳米粒子剥离.
- 释放的超小MNP/DOX (<10nm) 实现了深度瘤透和增强细胞内杀伤.
- 在体内实现了惊人的74.2%的瘤回归.
结论:
- 开发的NIR触发纳米粒子系统成功地整合了PTT和化疗.
- 这种可控制,尺寸可切换的纳米系统证明了高效的瘤积累和透.
- 该系统具有显著的潜力,可以改善对瘤的协同光化疗效应.
相关概念视频
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...