在被诊断患有呼吸道过敏疾病的兄弟姐妹中对过敏原的差异和相关性分析
Liping Liu1, Weihua Wang2, Yuemei Sun1
1Department of Allergy, Yantai Yuhuangding Hospital, Yantai, China.
International archives of allergy and immunology
|September 5, 2023
概括
较大的兄弟姐妹过敏于常见的过敏原,如灰尘或食物增加了年轻兄弟姐妹发展类似过敏的风险. 这项研究探讨了呼吸道过敏疾病中的兄弟过敏模式.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 儿科过敏 儿科过敏
- 过敏疾病的遗传学
背景情况:
- 父母担心后来的孩子会对相同的过敏原产生过敏.
- 关于兄弟姐妹过敏的现有研究主要集中在双胞胎身上,限制了现实世界的适用性.
- 这项研究调查了患有呼吸道过敏疾病的非双胞胎兄弟姐妹的过敏原敏感性.
研究的目的:
- 在被诊断患有呼吸道过敏疾病的兄弟姐妹中探索过敏原敏感性模式.
- 为了确定老兄弟姐妹的过敏原敏感性是否与年轻兄弟姐妹的敏感性相关.
- 识别特定的过敏原,这些过敏原对兄弟姐妹传播过敏的风险更高.
主要方法:
- 包括98对被诊断患有喘和/或过敏性鼻炎的兄弟姐妹.
- 收集了有关人口统计,食史,血清总IgE (TIgE),绝对乙酸细胞计数和过敏原特定IgE (sIgE) 的数据.
- 分析了六个过敏原类别的sIgE数据,比较了年长和年轻的兄弟姐妹群体.
主要成果:
- 在年长和年轻的兄弟姐妹或性别之间,总体过敏原阳性率,TIgE或乙素计数没有显著差异.
- 对灰尘,真菌,杂草花粉或食物过敏的年长兄弟姐妹在统计学上显著增加了对年轻兄弟姐妹对相同过敏原敏感的风险 (p < 0.05).
- 针对过敏原的特定IgE值 (除了灰尘) 在兄弟对之间有显著的相关性 (p <0.05).
结论:
- 对于过敏原敏感性的兄弟一致性存在,特别是对于灰尘,真菌,杂草花粉和食物过敏原.
- 年长兄弟姐妹的敏感性是年轻兄弟姐妹对特定过敏原的敏感性的重要预测因素.
- 研究结果强调了家庭病史在评估儿童过敏风险方面的重要性.
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