人类隔离的H3N8禽流感病毒在之间通过空气传播

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Updated: Jul 17, 2025

Influenza A Virus Studies in a Mouse Model of Infection

Influenza A Virus Studies in a Mouse Model of Infection

Published on: September 7, 2017

Honglei Sun¹, Han Li¹, Qi Tong¹

¹National Key Laboratory of Veterinary Public Health and Safety, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.

|September 5, 2023

概括

禽流感H3N8病毒可能会传播给人类,在动物模型中引起严重疾病. 人类群体可能缺乏免疫力,造成广泛爆发的风险.

科学领域:

病毒学
传染性疾病
公共卫生

背景情况:

H3N8禽流感病毒 (AIV) 在家禽中普遍存在,但其动物感染潜力尚不清楚.
在2022-2023年,中国报告了两例人类感染和一个致命的H3N8 AIV病例.

研究的目的:

调查H3N8 AIV的动物感染潜力和致病性.
评估H3N8 AIV对人类群体的风险.

主要方法:

人体支气管和肺上皮细胞的体外感染.
在小鼠和中进行的体内致病性和传染性研究.
对病毒受体结合偏好和遗传突变的分析.

主要成果:

在人类肺细胞中有效地感染和复制H3N8 AIV.
人类H3N8分离物呈现出更高的毒性,与分离物相比,在哺乳动物中引起严重的病理.
一种人类的H3N8分离物在中表现出空气传染性,获得了类似人类的受体结合和PB2-E627K突变.

结论:

H3N8 AIV具有动物传染的潜力,并且可以适应人类对人类的有效传播.
人类群体可能在免疫学上对这些新出现的病毒无知,从而增加了流行病的风险.
在禽类和人类群体中对H3N8 AIV的持续监测至关重要.

关键词:

H3N8亚型在空中传播禽流感病毒生物特性子动物感染

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Viral Recombination

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.