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通过通过LKB1核保留抑制AMPK活动,MKP1促进非酒精性脂肪肝炎

Bin Qiu1,2, Ahmed Lawan3, Chrysovalantou E Xirouchaki4,5

  • 1Yale University School of Medicine, Department of Pharmacology, 333 Cedar Street, New Haven, CT, 06520, USA.

Nature communications
|September 5, 2023
PubMed
概括

核MKP1抑制AMPKα,促进肝细胞死亡和非酒精性脂肪肝炎 (NASH). 删除MKP1激活AMPKα,防止NASH的发展和肝损伤.

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