68Ga-bisphosphonates用于通过正子发射断层扫描对骨外化的成像
George P Keeling1, Friedrich Baark1, Orestis L Katsamenis2
1Department of Imaging Chemistry & Biology, School of Biomedical Engineering & Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.
与[18F]NaF相比,双酸盐 (BPs) 提供了与骨外化 (EC) 的优越成像. 基于BP的标志物检测到各种矿物质,有助于在各种器官中早期检测EC.
科学领域:
- 核医学就是核医学.
- 放射性药物化学 放射性药物化学
- 分子成像学分子成像学
背景情况:
- 放射性标记双酸盐 (BPs) 和[F]NaF用于成像.
- [18F]NaF被广泛用于骨外化 (EC) 成像,选择性地与酸 (HAp) 结合.
- 欧共体的成分包括各种非HAp矿物质,这表明BP的更广泛的结合可能是有利的.
研究的目的:
- 为了比较双酸盐标记物 ([68Ga]Ga-THP-Pam) 和[18F]NaF的灵敏度,用于成像骨外化 (EC).
- 调查基于双酸盐的标记剂在检测EC中更广泛的矿物的潜力.
主要方法:
- 在EC的老鼠模型中对[68Ga]Ga-THP-Pam和[18F]NaF进行PET成像.
- 临床前CT和微CT (μCT) 用于宏观和微化识别.
- 扫描电子显微镜 (SEM) 和能量分散式X射线光谱 (EDX) 用于矿物分析.
主要成果:
- 这两种痕迹仪在骨成像中表现相似.
- [68Ga]Ga-THP-Pam在具有非HAp矿物成分的器官中检测EC的敏感性更高.
- 与NaF相比,基于BP的追踪器可以在体内检测到更广泛的矿物质.
结论:
- 基于双酸盐的PET标记剂,如[68Ga]Ga-THP-Pam,由于它们能够结合各种矿物质,因此对成像EC更敏感.
- 基于BP的标记剂为敏感和早期检测EC提供了优势.
- 基于BP的PET标记物用于EC成像的临床评估是有必要的.
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