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USP2通过duebiquitination和PD-L1的稳定促进瘤免疫逃避

Zean Kuang1, Xiaojia Liu2, Na Zhang1

  • 1Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.

Cell death and differentiation
|September 5, 2023
PubMed
概括

乌比基特异性加工蛋白酶2 (USP2) 在癌细胞中稳定了被编程死亡联体-1 (PD-L1). 抑制USP2降低PD-L1,增强抗瘤免疫力和T细胞介导杀死,表明USP2是治疗点.

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