皮层和皮层下形态变化及其与REM睡眠行为障碍中认知障碍的关系
Christiane Mala1, Filip Havlík2, Josef Mana3
1Department of Biomedical Informatics, Faculty of Biomedical Engineering, Czech Technical University in Prague, Prague, Czech Republic.
概括
孤立的REM睡眠行为障碍 (iRBD) 患者表现出认知缺陷,特别是心理运动速度和记忆,与大脑结构变化有关. 这些发现与iRBD中的特定大脑区域体积相关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 睡眠医学 睡眠医学
背景情况:
- 很少有研究在孤立的REM睡眠行为障碍 (iRBD) 中研究了结构性大脑变化和认知表现.
- 现有的关于iRBD中大脑形态和认知的研究是不确定的.
研究的目的:
- 为了评估与健康对照组相比,iRBD患者的大脑形态-认知性能关联的差异.
- 在iRBD中探索特定的大脑结构体积和认知功能之间的相关性.
主要方法:
- 对63名iRBD患者和36名对照进行了MRI扫描 (3T) 和综合的神经心理测试.
- iRBD患者被分为具有 (iRBD-MCI) 和没有 (iRBD-NC) 轻度认知障碍的患者.
- 基于voxel的形态测量 (VBM) 和基于变形的形态测量 (DBM) 分析了高分辨率T1加权的MRI图像.
主要成果:
- 在iRBD患者和使用VBM,DBM或ROI体积比较的对照组之间没有发现显著的结构差异.
- 在iRBD患者中,VBM揭示了皮层/皮下结构 (,,叶,小脑,基底) 和心理运动速度和记忆的测试之间的相关性.
- 在涉及处理速度的测试中,认知分析显示iRBD-MCI和iRBD-NC组之间存在显著差异.
结论:
- iRBD与认知缺陷有关,特别是心理运动速度和视觉注意力 (例如,TMT-A).
- 这些认知障碍与大脑区域的形态变化相关,包括条纹体,胰岛,小脑,叶,皮和杏仁体.
关键词:
认知能力 认知能力 认知能力轻度认知障碍 轻度认知障碍产品类型 产品类型快速眼动睡眠没有动.综核蛋白病变 (Synucleinopathy) 是一种同核蛋白病变的疾病.步道制作测试 步道制作测试更多相关视频
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