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调查年轻和晚期发作的渐进性超核性麻之间的差异

Batoul A AlWazan^1,2, Indira Garcia-Cordero³, Blas Couto⁴

¹Memory Clinic, Toronto Western Hospital, Toronto, ON, Canada. Batoul.Alwazan@medportal.ca.

Journal of neurology

|September 5, 2023

概括

年轻发病的渐进性上核性麻 (PSP) 患者更有可能表现出言语和语言缺陷. 早期发病年龄可以预测特定的PSP表型,提供临床和预后见解.

科学领域:

神经学神经学
神经退行性疾病神经退行性疾病
临床的表型化临床的表型化

背景情况:

发病年龄对渐进性上核性麻 (PSP) 现象型的影响仍未得到充分研究.
一个假设表明,年轻发病PSP (YOPSP) 和晚发病PSP (LOPSP) 之间存在不同的表现.

研究的目的:

为了比较YOPSP和LOPSP之间的临床表型和残疾进展率.
识别表现症状和满足诊断标准的差异.

主要方法:

根据MDS 2017标准对107名被诊断患有PSP的患者进行了回顾性分析.
根据65岁的年龄截止值将患者分为YOPSP和LOPSP.
对比了表型,症状,MDS核心标准和疾病严重程度 (PSP-RS).

主要成果:

在YOPSP患者中,PSP语音/语言 (SL) 表型 (18%vs0%) 和失言症 (16%vs1.4%) 的患病率更高.
语音和语言功能障碍 (C1) 在YOPSP中更常见 (33.3%对12.2%).
纵向PSP-RS数据表明,在6个月后,YOPSP中的圆柱体得分恶化更快.

结论:

年轻发病的PSP经常与语音和语言变异有关.
发病年龄是PSP表型的潜在预测因素,具有重要的临床和预后影响.

关键词:

晚期开始的PSP是PSP.运动障碍运动障碍公共服务提供商的现象类型在PSP上提供服务.渐进性的超核性.罗斯西公共公共服务中心中心年轻发起的PSP.

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