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明显的嗅觉和味觉障碍是后急性COVID-19后遗症的现型
Verena Rass1, Piotr Tymoszuk2, Sabina Sahanic3
1Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
概括
在COVID-19后的嗅觉功能障碍 (OD) 是常见的,恢复很慢. 一个特定的群体经历了持续的气味和味道损失,但保持了良好的生活质量和心理健康.
科学领域:
- 传染性疾病 传染性疾病
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 嗅觉功能障碍 (OD) 是2019年冠状病毒疾病 (COVID-19) 的常见症状之一.
- 了解OD的恢复轨迹和影响对于管理后急性COVID-19后果至关重要.
- 临床试验.gov的标识符:NCT04661462和NCT04416100.gov的标识符:NCT04661462和NCT04416100.gov的标识符:NCT04661462和NCT04416100.gov的标识符:NCT04661462和NCT04416100.gov的标识符:NCT04661462和NCT04416100.
研究的目的:
- 为了研究在SARS-CoV-2感染 (野生型和α变体) 后嗅觉功能障碍 (OD) 解决的动力学.
- 评估OD对生活质量,身体健康和心理健康的影响.
- 为了确定后急性COVID-19后遗症的不同表型.
主要方法:
- 在门诊COVID-19调查 (n=906) 和观察队列 (n=108) 中评估了OD患病率,并进行了长期随访.
- 利用多维缩放,关联规则挖掘和半监督集群来分析症状的同时发生和影响.
- 检查了生活质量,身体和心理健康结果与OD恢复有关的结果.
主要成果:
- 在急性COVID-19期间自我报告的OD的高患病率 (在调查中为72%,在队列中为41%).
- 从OD观察到缓慢的恢复,平均时间为28天 (调查) 和90天 (观察队列).
- 确定了一组持续的嗅觉和味觉障碍,但身体/精神恢复良好的人群,与疲劳或神经认知症状的人群不同.
结论:
- 后急性COVID-19后果是异质的,需要量身定制的管理策略.
- 一种特定的持续性嗅觉和味觉障碍的表型显示出良好的临床,身体和精神恢复.
- 这种独特的表型可能对公共卫生倡议构成可管理的挑战.
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