概括
呼吸道病毒可以通过各种机制增强真菌感染,增加死亡率. 开发新的抗真菌疗法对于对抗这些协同感染引起的潜在未来流行病至关重要.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 呼吸道真菌和病毒感染,包括流感和SARS-CoV-2,可以独立导致高死亡率.
- 在呼吸道中同时感染真菌和病毒病原体可能导致死亡率的协同增长.
研究的目的:
- 探索病毒操纵如何促进二次真菌感染.
- 评估由病毒诱导的多药耐药性真菌感染驱动的未来流行病的潜力.
主要方法:
- 关于抑制宿主免疫反应的已知病毒机制的审查.
- 对病毒操纵促进二次真菌病原体感染的潜力的分析.
- 考虑跨物种传播和病毒-真菌相互作用的演变.
主要成果:
- 病毒使用至少五种策略来帮助二次真菌感染,包括免疫抑制和细胞通路的操纵.
- 虽然细菌共同感染在历史上增加了病毒大流行病死亡率,但病毒对真菌病原体的操纵构成了未来的重大威胁.
- 由于动物种群中广泛的特有感染,涉及多种耐药性真菌病原体的流行病的可能性是合理的,由呼吸道病毒促进的.
结论:
- 病毒对宿主防御的操纵为二次真菌感染创造了有利的环境,可能会增加死亡率.
- 病毒的进化促进多药耐药的真菌病原体可能导致严重的,无法治疗的流行病.
- 积极开发新型抗真菌疗法对于应对这些潜在的全球卫生危机至关重要.
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