相关实验视频
Updated: Jul 17, 2025

08:20
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
11.3K
在性状完好无损的奇华娃狗中,阿尔多-孕的关系
Alberto Galizzi1, Greta Dossi2, Vitaliano Borromeo2
1Department of Veterinary Medicine and Animal Science, University of Milan, Via dell'Università 6, Lodi, 26900, Italy. alberto.galizzi@unimi.it.
BMC veterinary research
|September 5, 2023
概括
雌性狗的孕水平与阿尔多相关,这表明生殖周期会影响激素水平. 这一发现对于准确评估犬类的阿尔多素至关重要.
科学领域:
- 兽医内分泌学 兽医内分泌学
- 狗的繁殖 狗的繁殖
- 激素检测测试验 激素检测试验
背景情况:
- 阿尔多是心力衰竭治疗的关键标,也是氨酸- ангиотензин-阿尔多素系统活性的指标.
- 鉴于个体因素,评估阿尔多素可能具有挑战性,之前的研究指出,在完整的雌性狗中,尿中阿尔多素与肌素的比率较高.
- 孕激素对阿尔多斯特的影响已在人类和动物中记录下来,但尚未在狗中进行研究.
研究的目的:
- 为了研究孕激素和阿尔多斯特之间的关系在性状完整的奇华娃雌性.
- 测量无期 (基线前) 和二期 (高前) 期间的血清前和尿路阿尔多.
主要方法:
- 一项前性研究,涉及14名性状完整的奇华娃雌性.
- 每只狗的激素水平 (血清孕激素,尿路阿尔多,尿路阿尔多与肌素的比率) 测量两次:在无月期和二月期.
- 统计分析包括相关性 (斯皮尔曼的rho) 和显著性测试 (P值).
主要成果:
- 血清孕和尿路阿尔多斯在二期与无期相比显著更高 (分别P < 0.001和P = 0.01).
- 尿液中阿尔多素与肌素的比率在二期较高,但没有达到统计学意义 (P = 0.056).
- 血清孕激素与尿路阿尔多素 (ρ = 0.638,P < 0.001) 和尿路阿尔多素与肌素的比率 (ρ = 0.516,P = 0.005) 都显示出中等的正相关性.
结论:
- 建议在犬类中进行孕激素-阿尔多斯特关系.
- 在解释狗的阿尔多斯激素度时,应考虑生殖周期的阶段.
- 需要对更大种群进行进一步的研究来证实这些发现并阐明潜在的机制.
相关概念视频
Ovarian Cycle
1.3K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.3K
Hormonal Control of the Ovarian Cycle
565
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
565
Gonadal and Placental Hormones
1.5K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.5K
Hormonal Regulation of the Menstrual Cycle
435
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
435
Hormones of the Adrenal Glands
2.6K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
2.6K
Hormonal Regulation
33.3K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
33.3K

