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腹腔透析患者的三糖糖体质指数和心血管死亡率:一个回顾性队列研究

Cuixia Zhan^1,2, Yuan Peng^1,2,3, Hongjian Ye^1,2

¹Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, 58th, Zhongshan Road II, Guangzhou, 510080, China.

Lipids in health and disease

|September 5, 2023

概括

较高的甘油三糖-体质指数 (TyG-BMI) 与患腹腔透析 (PD) 患者心血管疾病 (CVD) 和整体死亡风险的增加有关. 这一发现强调了TyG-BMI作为这个脆弱人群中死亡率的潜在预测因素.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
心脏病学心脏病学
代谢综合征是代谢综合征的一种.

背景情况:

三糖糖体质量指数 (TyG-BMI) 是新出现的代谢功能障碍的标志物.
以前的研究将TyG-BMI与心血管疾病 (CVD) 和缺血性中风联系起来.
在腹腔透析 (PD) 患者中,TyG-BMI和心血管疾病死亡率之间的关联仍未得到充分研究.

研究的目的:

调查中国南部PD患者基线TyG-BMI和心血管疾病死亡率之间的关系.
评估TyG-BMI作为该队列中所有原因死亡率的预测指标.

主要方法:

一个单一中心的回顾性队列研究包括2335例PD患者 (2006-2018).
使用禁食血葡萄糖,甘油三和BMI计算了TyG-BMI.
用多变量调整的Cox比例危险回归模型来评估死亡风险.

主要成果:

队列 (平均年龄46.1岁,59.2%的男性,24.2%的糖尿病患者) 的 TyG-BMI 中位数为183.7.7.
在46.6个月的中位数随访期间,发生了615例死亡,其中297例死于心血管疾病.
较高的TyG-BMI独立地与心血管疾病死亡率 (HR 1.51) 和所有原因死亡率 (HR 1.36) 的增加有关.
在TyG-BMI中,1 SD的增加与28%更高的心血管疾病死亡风险和19%更高的全因死亡风险相关联.

结论:

基线TyG-BMI升高是PD患者心血管疾病和全因死亡率的独立预测因子.
泰格-BMI可能会成为PD患者的宝贵风险分层工具.
进一步的研究应该探索在这个人群中修改TyG-BMI的干预措施.

关键词:

心血管死亡率的心血管死亡率腹膜透析是指腹膜透析.在TyG-BMI中.

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