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相关概念视频

Drug Delivery: Overview01:16

Drug Delivery: Overview

321
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
321
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

379
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
379
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

503
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
503
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

608
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
608

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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
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量身定制的药物输送平台:刺激响应的核心外结构化纳米载体.

Yulong Shi1, Yiran Zhang2, Liangliang Zhu3

  • 1School of Materials and Chemistry & Institute of Bismuth and Rhenium, University of Shanghai for Science and Technology, Shanghai, 200093, China.

Advanced healthcare materials
|September 6, 2023
PubMed
概括

响应刺激的核心外纳米载体提供先进的药物输送. 本综述详细介绍了智能治疗应用的设计和受控释放机制.

关键词:
核心-外结构的核心-外结构药物输送系统是药物输送系统.纳米载体的纳米载体刺激对刺激的反应性.

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科学领域:

  • 材料化学 材料化学
  • 生物医学是生物医学.
  • 纳米技术纳米技术

背景情况:

  • 核心纳米载体正因其独特的特性和多样化的应用而引起人们的注意.
  • 量身定制的核心外结构是开发智能药物输送系统的关键领域.
  • 对应刺激的核心纳米载体的系统性审查,专注于设计和释放机制,是有限的.

研究的目的:

  • 提供对刺激响应的核心外纳米载体的全面审查.
  • 根据药物加载方法对纳米载体进行分类.
  • 通过刺激-反应过程突出控制释放机制.

主要方法:

  • 根据药物有效载荷对核心纳米载体的分类.
  • 环境刺激引发的受控释放机制的分析.
  • 讨论核心纳米载体作为药物载体的设计前景.

主要成果:

  • 各种核心外纳米载体设计及其药物加载能力的概述.
  • 详细解释了对刺激反应的控制释放策略.
  • 探索先进药物输送的多方面的设计考虑.

结论:

  • 核心外纳米载体对智能药物输送充满希望.
  • 了解刺激-反应机制对于优化纳米载体设计至关重要.
  • 本综述为开发先进的纳米载体提供了洞察力和未来前景.