基于现实实践的Nomogram用于预测患有大 (>5厘米) 肝细胞癌的患者的整体存活率
Nalee Kim1, Jeong Il Yu1, Hee Chul Park1
1Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Journal of liver cancer
|September 6, 2023
概括
一种新型的诺米图准确地预测了大型肝细胞癌 (HCC) 患者的生存率. 这种工具有助于估计这个具有挑战性的癌症的个体结果,帮助治疗决策.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 医学统计 医学统计
背景情况:
- 大型肝细胞癌 (>5厘米) 具有有限的治疗选择.
- 确定预后因素对于开发HCC管理中的预测工具至关重要.
研究的目的:
- 确定大HCC患者整体存活期 (OS) 的预后因素.
- 构建和验证一个名谱来预测这个患者群体的生存结果.
主要方法:
- 在2015-2018年期间诊断出438名患有大型HCC的患者的分析.
- 利用考克斯的比例危险模型来确定OS的预测因素.
- 开发并通过交叉验证和引导来验证一个名ogram.
主要成果:
- 平均生存期为9.9个月,一年生存率为43.9%.
- 确定了关键的预后因素:表现状况,MELD等级,瘤大小,门静脉瘤血栓症和初始治疗.
- 诺米图表显示了有利的准确性,对应度指数为0.807.
结论:
- 一种新型的诺米图准确地估计了大型HCC患者的个人存活率.
- 开发的工具为预测这一群体的结果提供了可接受的准确性.
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