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An R-Based Landscape Validation of a Competing Risk Model
Published on: September 16, 2022
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软件应用程序简介: dynamicLM - - 一种使用具有里程碑意义的超级模型进行动态风险预测的工具,用于在竞争性风险下的生存数据
Anya H Fries1, Eunji Choi1, Julie T Wu2
1Quantitative Sciences Unit, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
International journal of epidemiology
|September 6, 2023
概括
动态LM R包提供了一种灵活的工具,用于使用具有竞争风险的里程碑式模型预测疾病进展. 它通过提供动态的生存数据评估来增强个性化医疗.
科学领域:
- 生物统计学 生物统计学
- 医疗信息学 医疗信息学
- 计算生物学 计算生物学
背景情况:
- 动态预后评估对于个性化医学至关重要.
- 里程碑式的模型为预测疾病进展提供了强大的工具.
- 现有的框架缺乏灵活性,以应对不同的结果,如竞争风险.
研究的目的:
- 引入 dynamicLM,这是一个易于使用的 R 包,用于里程碑式的模型.
- 为了促进在竞争性风险下对生存数据的动态预测.
- 为数据准备,建模,预测和绩效评估提供全面的工具.
主要方法:
- 动态LM R包实现了特定原因的里程碑模型.
- 它结合了时间变化的协变量和时间依赖的预测效应.
- 该包支持具有或没有竞争风险的生存数据.
主要成果:
- dynamicLM提供了用于数据准备,模型拟合和预测的功能.
- 它包括用于评估预测性能的工具,如时间依赖的AUC和Brier分数.
- 该软件包在GitHub上可供公众访问和使用.
结论:
- 动态LM解决了对地标建模的灵活和全面工具的需求.
- 它使得在存在竞争性风险的情况下,能够动态预测生存结果.
- 这个R包推进了在个性化医学和生存分析中的里程碑式模型的应用.
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