对于心力衰竭患者的empagliflozin的跨国成本效益分析,喷射分数>40的患者
Spyros Kolovos1, Leana Bellanca2, Harinala Groyer3
1IQVIA, Athens, Greece.
ESC heart failure
|September 6, 2023
概括
恩帕格利弗洛辛加标准护理是心力衰竭的第一种有效治疗方法,具有保存的喷射分数 (HF LVEF > 40%),为英国,西班牙和法国的医疗保健系统提供了显著的临床益处和成本效益.
科学领域:
- 心脏病学 心脏病学
- 卫生经济学 卫生经济学
- 药物经济学 药物经济学
背景情况:
- 保持喷射分数的心力衰竭 (HF LVEF> 40%) 对患者和医疗保健系统构成重大负担.
- 从历史上看,在empagliflozin获得批准之前,这种疾病的有效治疗选择有限.
研究的目的:
- 在英国,西班牙和法国,评估empagliflozin加标准护理 (SoC) 与SoC单独用于HF LVEF>40%的成本效益.
- 量化与管理这些患者相关的医疗保健成本.
主要方法:
- 使用终身马尔科夫队列状态过渡模型,基于堪萨斯城心肌病问卷-临床总结得分四分位数的健康状况.
- 模型输入来自EMPEROR-Preserved试验,出版文献,国家特定数据库和当地经济评估指南.
主要成果:
- 除了SoC,Empagliflozin还增加了1407英 (英国),1148欧元 (西班牙) 和1485欧元 (法国) 的成本.
- 然而,它显著减少了HF或心血管死亡的住院治疗,抵消了药物采购成本.
- 每个经过质量调整的寿命年 (QALY) 的增量成本效益比率是有利的:£14,851 (英国),€11,706 (西班牙) 和€15,447 (法国).
结论:
- 恩帕格利弗洛辛是第一个有针对性的治疗方法,其临床疗效和成本效益对于HF LVEF>40%的治疗是显著的.
- 它与SoC的使用预计将提高临床结果和患者的生活质量.
- 在英国,西班牙和法国,这种治疗在接受的支付意愿门内具有成本效益.
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